- Fall 2022
- Location: Animal Science A228
- Time: 9:00-9:50am (MWF)
- Prerequisites: STAT-801A or equivalent, or permission of the instructor(s).
Texts and Reading Materials
Required textbook
- Falconer & Mackay, Introduction to Quantitative Genetics
Free Online Materials
- Graham Coop, Population Genetics notes
- Basic R: Quick online reference for data input, basic statistics, and plots.
- STHDA: Statistical tools for high-throughput data analysis.
Schedule Fall 2022
The HTML slides will likely be posted on Sunday pm for the next week. The slides are subject to change before the class.
Week 1: Allele and Genotype Frequencies (Ch1)
- 08-22 (M): Introduction [HTML]
- 08-24 (W): Hardy-Weinberg Equilibrium [HTML]
- 08-26 (F): Linkage Disequilibrium [HTML]
Week 2: Changes of Allele Frequency (Ch2 & Ch3)
- 08-29 (M): Migration, Mutation, and Selection [HTML]
- HW1 assigned in Canvas (Due Friday morning)
- 08-31 (W): Effectiveness of Selection [HTML]
- 09-02 (F): Genetic Drift [HTML]
- HW1 Due today!
Week 3: Small Populations — simplified conditions (Ch3 & Ch4)
Week 4: Small Populations — less simplified conditions (Ch4)
Week 5: Population Structure and Neutrality test (Notes in Canvas)
- 09-19 (M): F-statistics [HTML]
- HW2 assigned in Canvas!
- 09-21 (W): Neutral theory [HTML]
- 09-23 (F): Dececting natural selection [HTML]
Week 6: Pedigreed Population and Close Inbreeding (Ch5)
- 09-26 (M): Pedigreed Population [HTML]
- HW2 Due today!
- 09-28 (W): Coancestry [HTML]
- 09-30 (F): Relationship matrix [HTML]
- Journal article assigned for peer review
Week 7: Statistical Foundations for Continuous Variation (Ch6 and Notes in Canvas)
- 10-03 (M): Statistical Foundations [HTML]
- 10-05 (W): Continuous Variation [HTML]
- 10-07 (F): Journal Review Discussion [HTML]
- Peer review due
Week 8: Population values and means (Ch7)
- 10/10 (M): Average effect of an allele [HTML]
- 10/12 (W): Breeding value, dominance, and interaction
[HTML]
- HW3 assigned in Canvas (Due Next Wednesday morning)
- 10/14 (F): Breeding value interpretation [HTML]
Week 9: Genetic components of variance (Ch8)
- 10/17 (M): No Class [Enjoy your Fall Break!]
- 10/19 (W): Variance partitioning [HTML]
- HW3 Due today!
- 10/21 (F): Exam II
Week 10: Heritability and Resemblance between relatives (Ch8 & Ch9)
- 10/24 (M): Heritability and Repeatability [HTML]
- 10/26 (W): Genetic covariance [HTML]
- 10/28 (F): Genetic and environmental covariance [HTML]
Week 11: Heritability estimation (Ch10)
- 10/31 (M): Estimation of heritability [HTML]
- Notes in Canvas
- HW4 assigned
- 11/02 (W): Precision of estimates [HTML]
- 11/04 (F): Examples for h2 estimation [HTML]
Week 12: Predicting response to selection (Ch11 & Ch12)
- 11/07 (M): The breeder’s equation [HTML]
- HW4 due today
- 11/09 (W): Variability in response [HTML]
- 11/11 (F): Asymmetry of responses [HTML]
- No meeting, watching recorded class video
Week 13: Selection: Empirical results and interpretation (Ch12 & Ch14)
- 11/14 (M): Long-term results [HTML]
- 11/16 (W): Exam III
- 11/18 (F): Inbreeding depression and heterosis [HTML]
Week 14: Correlated traits (Ch19)
- 11/21 (M): Correlated responses to selection [HTML]
- 11/23 (W): No Class (Student Holiday)
- 11/25 (F): No Class and Happy Thanksgiving!
Week 15: Correlated traits and Quantitative trait loci (Ch19 & Ch21)
- 11/28 (M): Correlated traits: Index selection [HTML]
- HW5 assigned
- 11/30 (W): QTL: Single-marker analysis [HTML]
- 12/02 (F): QTL: Interval Mapping [HTML]
Final exam
- 12/09 (F): 9:00-10:00am